منابع مشابه
Further investigations regarding the toxicity of sodium nitroprusside.
Sodium nitroprusside is a valuable vasodilator, but its use has been curtailed because of numerous reports that, in the presence of blood, nitroprusside decomposes with release of toxic cyanide. We have examined the release of cyanide in terms of the known chemistry of nitroprusside and suggest that photochemical decomposition of nitroprusside and (or) its metabolism in vivo invalidates the ana...
متن کاملSodium Nitroprusside Injection
Except when used briefly or at low (< 2 mcg/kg/min) infus ion rates , sodium nitropruss ide gives rise to important quantities of cyanide ion, which can reach toxic, potentially lethal levels (see WARNINGS). The usual dose rate is 0.5 to 10 mcg/kg/min, but infus ion at the maximum dose rate should never las t more than 10 minutes . If blood pressure has not been adequately controlled after 10 m...
متن کاملDeliberately Lowering Blood Pressure with Sodium Nitroprusside
The goal of hyptensive anesthesia is the safe reduction of intraoperative blood loss, thus reducing transfusion risks. Previous hypotensive technics had a narrow margin of safety in that cardiac output was usually reduced in proportion to the degree of induced hypotension. This is in contrast to the results of our study, in which Sodium Nitroprusside was used as the sole hypotensive agent. Ni...
متن کاملSodium nitroprusside: theory and practice.
Sodium nitroprusside, by a peripheral vasodilator action, is a powerful hypotensive drug. In contrast to established agents, its hypotensive action is accompanied by an unchanged or augmented cardiac output. Intravenous administration of sodium nitroprusside rapidly produces a profound and controllable hypotension. Normotension is swiftly restored by ceasing to infuse the agent, and antidotes a...
متن کاملCyanide toxicity following nitroprusside induced hypotension.
Several recently reported deaths following the use of sodium nitroprusside have been attributed to the accumulation of the nitroprusside metabolite, cyanide. In this study, brief nitroprusside infusions (mean = 36 minutes) were administered in currently recommended doses during intracranial surgery. The peak blood cyanide following the infusions was 65.2 +/- 17.5 microgram per cent (mean +/- SE...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1974
ISSN: 0007-0912
DOI: 10.1093/bja/46.12.952